Pharmacology - faculty

Yuichiro J. Suzuki

Professor of Pharmacology
Ph.D., Physiology and Biophysics
Medical College of Virginia, 1991

AHA Postdoctoral Fellow
University of California, Berkeley

(202) 687-8090
ys82@georgetown.edu

Suzuki Lab: CLICK HERE for updated information http://www9.georgetown.edu/faculty/ys82/SuzukiLab.htm

My laboratory investigates signal transduction and transcriptional regulatory mechanisms for growth and death of pulmonary vascular smooth muscle cells and right ventricular cardiac muscle cells. Our goal is to develop therapeutic strategies to treat patients with pulmonary hypertension. Pulmonary hypertension is a devastating disease without cure, characterized by increased blood pressure in pulmonary circulation due to increased vasoconstriction and cell growth. Increased pulmonary vascular resistance eventually leads to right heart failure and death.

Research Support

R01 HL72844 “Mechanism of apoptosis in lung vascular smooth muscle”

R01 HL97514 “Oxidant signaling for airway remodeling and inflammation”

Selected Publications:

Liu L, Marcocci L, Wong CM, Park AM, Suzuki YJ.: Serotonin-mediated protein carbonylation in the right heart Free Radic Biol Med. 45:847-54, 2008

Lee YH, Suzuki YJ, Griffin AJ, Day RM.: Hepatocyte growth factor regulates cyclooxygenase-2 expression via beta-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells. Free Radic Biol Med. 45:847-54, 2008

Wong CM, Cheema AK, Zhang L, Suzuki YJ.: Protein carbonylation as a novel mechanism in redox signaling. Circ Res. 102:310-8, 2008

Park AM, Nagase H, Kumar SV, Suzuki YJ.: Effects of intermittent hypoxia on the heart. Antioxid Redox Signal. 9:723-9, 2007

Suzuki YJ.: From oxygen sensing to heart failure. Antioxid Redox Signal. 9:653-60, 2007

Suzuki YJ, Nagase H, Wong CM, Kumar SV, Jain V, Park AM, Day RM.: Regulation of Bcl-xL expression in lung vascular smooth muscle. Am J Respir Cell Mol Biol. 36:678-87, 2007

Park AM, Suzuki YJ.: Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice. J Appl Physiol. 102:1806-14, 2007

Park AM, Nagase H, Vinod Kumar S, Suzuki YJ.: Acute intermittent hypoxia activates myocardial cell survival signaling. Am J Physiol Heart Circ Physiol. 292:H751-7, 2007

Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, Long CS, Rubin LJ, Smart FW, Suzuki YJ, Gladwin M, Denholm EM, Gail DB; National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure.: Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation. 114:1883-91, 2006

Suzuki YJ, Jain V, Park AM, Day RM.: Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radic Biol Med. 40:1683-92, 2006

Day RM, Lee YH, Park AM, Suzuki YJ.: Retinoic acid inhibits airway smooth muscle cell migration. Am J Respir Cell Mol Biol. 34:695-703, 2006

Day RM, Agyeman AS, Segel MJ, Chévere RD, Angelosanto JM, Suzuki YJ, Fanburg BL.: Serotonin induces pulmonary artery smooth muscle cell migration. Biochem Pharmacol. 71:386-97, 2006

Suzuki YJ, Nagase H, Nie K, Park AM.: Redox control of growth factor signaling: recent advances in cardiovascular medicine. Antioxid Redox Signal. 7:829-34, 2005

Preston IR, Tang G, Tilan JU, Hill NS, Suzuki YJ.: Retinoids and pulmonary hypertension. Circulation. 111:782-90, 2005

Suzuki YJ, Nagase H, Day RM, Das DK.: GATA-4 regulation of myocardial survival in the preconditioned heart. J Mol Cell Cardiol. 37:1195-203, 2004

Liu Y, Suzuki YJ, Day RM, Fanburg BL.: Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ Res. 95:579-86, 2004

Suzuki YJ, Evans T.: Regulation of cardiac myocyte apoptosis by the GATA-4 transcription factor. Life Sci. 74:1829-38, 2004

Suzuki YJ.: Growth factor signaling for cardioprotection against oxidative stress-induced apoptosis. Antioxid Redox Signal. 5:741-9, 2003

Day RM, Suzuki YJ, Fanburg BL.: Regulation of glutathione by oxidative stress in bovine pulmonary artery endothelial cells. Antioxid Redox Signal. 5:699-704, 2003

Suzuki YJ, Griendling KK.: Redox control of growth factor signaling in heart, lung, and circulation. Antioxid Redox Signal. 5:689-90, 2003

Suzuki YJ.: Stress-induced activation of GATA-4 in cardiac muscle cells. Free Radic Biol Med. 34:1589-98, 2003

Suzuki YJ, Day RM, Tan CC, Sandven TH, Liang Q, Molkentin JD, Fanburg BL.: Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells. J Biol Chem.278:17525-31, 2003

Kim Y, Ma AG, Kitta K, Fitch SN, Ikeda T, Ihara Y, Simon AR, Evans T, Suzuki YJ.: Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis. Mol Pharmacol. 63:368-77, 2003

Kitta K, Day RM, Kim Y, Torregroza I, Evans T, Suzuki YJ.: Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells. J Biol Chem. 278:4705-12, 2003

Ihara Y, Suzuki YJ, Kitta K, Jones LR, Ikeda T.: Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin. Cell Calcium. 32:21-9, 2002

Day RM, Suzuki YJ, Lum JM, White AC, Fanburg BL.: Bleomycin upregulates expression of gamma-glutamylcysteine synthetase in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 282:L1349-57, 2002

Clément SA, Tan CC, Guo J, Kitta K, Suzuki YJ.: Roles of protein kinase C and alpha-tocopherol in regulation of signal transduction for GATA-4 phosphorylation in HL-1 cardiac muscle cells. Free Radic Biol Med. 32:341-9, 2002

Kitta K, Day RM, Remeika J, Blumberg JB, Suzuki YJ.: Effects of thiol antioxidants on hepatocyte growth factor signaling in cardiac myocytes. Antioxid Redox Signal. 3:911-8, 2001

Day RM, Yang Y, Suzuki YJ, Stevens J, Pathi R, Perlmutter A, Fanburg BL, Lanzillo JJ.: Bleomycin upregulates gene expression of angiotensin-converting enzyme via mitogen-activated protein kinase and early growth response 1 transcription factor. Am J Respir Cell Mol Biol. 25:613-9, 2001

Kitta K, Day RM, Ikeda T, Suzuki YJ.: Hepatocyte growth factor protects cardiac myocytes against oxidative stress-induced apoptosis. Free Radic Biol Med. 31:902-10, 2001

Kitta K, Clément SA, Remeika J, Blumberg JB, Suzuki YJ.: Endothelin-1 induces phosphorylation of GATA-4 transcription factor in the HL-1 atrial-muscle cell line. Biochem J. 359:375-80, 2001

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Yuichiro J. Suzuki

Professor of Pharmacology Ph.D., Physiology and Biophysics Medical College of Virginia, 1991

AHA Postdoctoral Fellow University of California, Berkeley (202) 687-8090 ys82@georgetown.edu

Professor of Pharmacology
Ph.D., Physiology and Biophysics
Medical College of Virginia, 1991

AHA Postdoctoral Fellow
University of California, Berkeley

(202) 687-8090
ys82@georgetown.edu