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Pearl Title	HCTZ vs. Chlorthalidone
Pearl ID	980
Author	Justin Tong
Content	Both HCTZ and chlorthalidone have demonstrated risk reduction in clinical trials. However, the largest trials, including Hypertension Detection and Follow-up Program (HDFP), MRFIT, Systolic Hypertension in the Elderly Program (SHEP), and ALLHAT, primarily used chlorthalidone as the initial therapy and more consistently showed reductions in cardiovascular events than did studies that primarily used HCTZ.
Source	Hypertension.Volume 43(1), January 2004, pp 4-9
Evidence Level	A-RCT/Meta-analysis
Question Type	foreground
Relevance	Disease-oriented evidence
Rotation	Family Medicine
Date Created	05/23/2008
Modified Date	05/23/2008
Starter Pearl?	No