SEQUEROME is a web-based Sequence Profiling Tool developed that provides a unique and useful functionality of profiling each of the BLAST results to enable the users to extract the maximum out sequence alignment reports.
Excerpts
from the publication on this web based tool...
"Sequence homology searches are commonly performed using
Basic Local Alignment Search Tool (BLAST; http://www.ncbi.nlm.nih.gov/BLAST).
However, the BLAST results interface does not provide direct simple access to
useful sequence analysis tools, such as restriction enzyme maps for DNA
sequences and secondary structure prediction for protein sequences. Moreover, it
is difficult to navigate smoothly between different sequence alignment records.
Therefore, there exists a need for a single interface that would allow a user to
directly link each of the sequences from alignment reports to different
domains/servers offering analysis and manipulation options. To meet this need,
we developed SEQUEROME, a Java-based tool that acts as a front-end to BLAST
queries and provides simplified access to web-distributed resources for protein
and nucleic acid analysis."
Some of the salient features of SEQUEROME include
1. Profiling Sequence alignment reports from BLAST
2. Three pane browsing environment allowing simultaneous input and analysis of multiple sequences.
3. Tabbed browsing allowing user to come back earlier operations, visit third party services to perform customized sequence manipulations - Refer right side on 'Advanced' OR 'Analyze/Manipulate' options of top panel .
4. Cached storage of input sequences - Click on "My Input History" on low right panel.
5. One-box any-format sequence input.
6. 'Print', 'Mail' and 'Save' options on top of each icon, for results from each pane
SEQUEROME is now officially listed as a tool in many servers and portals across the World, including
·
PIR - Protein Information Resource,
· Bioinformatics team (CVS & CIR) - Univ. of Edinburgh (UK)
· ExPASy - Swiss Institute of Bioinformatics,
·
IMGT - International Immuno-Genetics
Information system (
·
CBHD - Canadian Bioinformatics Help Desk
(
· SCIENCE magazine features SEQUEROME & InstaSeq (Sep 23 2005)
Citing SEQUEROME:
"A web based interface
facilitating sequence to structure analysis of BLAST alignment reports",
Natarajan Ganesan et.al., Biotechniques Volume 39, Number 2: pp
186-188
Research Team behind SEQUEROME
Credits & Acknowledgements
· Grants and Financial Support
· Databases and information sources
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